Duration of analgesia and pruritus following intrathecal fentanyl for labour analgesia: no significant effect of A118G m-opioid receptor polymorphism, but a marked effect of ethnically distinct hospital populations
نویسندگان
چکیده
Editor’s points † Genetic polymorphism in the m-opioid receptor can affect systemic opioid analgesia. † The effects of the A118G polymorphism on analgesia and pruritus after intrathecal fentanyl for labour analgesia were compared in two ethnically distinct populations. † While there was no effect of the genetic polymorphism, there was a marked effect of the ethnically distinct groups on duration of both analgesia and pruritus because of other factors. Background. Genetic polymorphism (A118G) in the m-opioid receptor has been reported to affect systemic opioid analgesia. However, reported pharmacogenetic effects on spinal opioid analgesia, particularly in labour, have been equivocal.
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